Professor Renier van der Hoorn: List of publications

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BGAL1 depletion boosts the level of β-galactosylation of N- and O-glycans in N. benthamiana.

Discovering the RNA-binding proteome of plant leaves with an improved RNA interactome capture method

Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases

Proteases of Nicotiana benthamiana: an emerging battle for molecular farming.

A homology-guided, genome-based proteome for improved proteomics in the alloploid Nicotiana benthamiana.

Activity-based proteomics reveals nine target proteases for the recombinant protein-stabilizing inhibitor SlCYS8 in Nicotiana benthamiana.

Re-targeting of a plant defense protease by a cyst nematode effector.

Triazine probes targeting ascorbate peroxidases in plants

Plant Biology: Proteolytic Release of Damage Signals.

Caught green-handed: methods for in vivo detection and visualization of protease activity.

Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides

Dynamic hydrolase labelling as a marker for seed quality in Arabidopsis seeds.

Generation of transgenic cell suspension cultures of the model legume Medicago truncatula: a rapid method for Agrobacterium mediated gene transfer

Sphingolipid-induced cell death in Arabidopsis is negatively regulated by the papain-like cysteine protease RD21.

A genotypic comparison reveals that the improvement in nitrogen remobilization efficiency in oilseed rape leaves is related to specific patterns of senescence-associated protease activities and phytohormones

Do proteolytic cascades exist in plants?

Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in Nicotiana benthamiana.

Enhancing cinnamon essential oil activity by nanoparticle encapsulation to control seed pathogens

Homology-guided re-annotation improves the gene models of the alloploid Nicotiana benthamiana

Low Protease Content in Medicago truncatula Cell Cultures Facilitates Recombinant Protein Production.

Species-specific antimicrobial activity of essential oils and enhancement by encapsulation in mesoporous silica nanoparticles

Protease Activities Triggered by Ralstonia solanacearum Infection in Susceptible and Tolerant Tomato Lines.

From structure to function - a family portrait of plant subtilases.

Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants.

N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway.

The transcriptome, extracellular proteome and active secretome of agroinfiltrated Nicotiana benthamiana uncover a large, diverse protease repertoire.

Unravelling the mode of action of plant proteases

An effector from the Huanglongbing-associated pathogen targets citrus proteases.

Ten Prominent Host Proteases in Plant-Pathogen Interactions.

Tricked or trapped-Two decoy mechanisms in host-pathogen interactions.

Defended to the Nines: 25 Years of Resistance Gene Cloning Identifies Nine Mechanisms for R Protein Function.

Proteomic Investigations of Proteases Involved in Cotyledon Senescence: A Model to Explore the Genotypic Variability of Proteolysis Machinery Associated with Nitrogen Remobilization Efficiency during the Leaf Senescence of Oilseed Rape.

Vacuolar processing enzyme activates programmed cell death in the apical meristem inducing loss of apical dominance.

Bodyguards: Pathogen-Derived Decoys That Protect Virulence Factors.

Plant life needs cell death, but does plant cell death need Cys proteases?

Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections.

Inhibitor Discovery by Convolution ABPP.

Major Cys protease activities are not essential for senescence in individually darkened Arabidopsis leaves.

Proteasome Activity Profiling Uncovers Alteration of Catalytic β2 and β5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots.

Papain-like cysteine proteases as hubs in plant immunity.

Screen of Non-annotated Small Secreted Proteins of Pseudomonas syringae Reveals a Virulence Factor That Inhibits Tomato Immune Proteases.

Activity-based protein profiling of hydrolytic enzymes induced by gibberellic acid in isolated aleurone layers of malting barley.

Capture of endogenously biotinylated proteins from Pseudomonas aeruginosa displays unexpected downregulation of LiuD upon iron nutrition.

The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity.

Twelve ways to confirm targets of activity-based probes in plants.

Nicotinamide Cofactors Suppress Active-Site Labeling of Aldehyde Dehydrogenases.

Characterization of senescence-associated protease activities involved in the efficient protein remobilization during leaf senescence of winter oilseed rape.

Decoy Engineering: The Next Step in Resistance Breeding.

Juggling jobs: roles and mechanisms of multifunctional protease inhibitors in plants.

Inspirational decoys: a new hunt for effector targets.

The Increasing Impact of Activity-Based Protein Profiling in Plant Science.

Beta galactosidases in Arabidopsis and tomato - a mini review.

Activity profiling reveals changes in the diversity and activity of proteins in Arabidopsis roots in response to nematode infection.

Functional Divergence of Two Secreted Immune Proteases of Tomato.

Subfamily-Specific Fluorescent Probes for Cysteine Proteases Display Dynamic Protease Activities during Seed Germination.

SNARE-RNAi results in higher terpene emission from ectopically expressed caryophyllene synthase in Nicotiana benthamiana.

Broad-range glycosidase activity profiling.

PIRIN2 stabilizes cysteine protease XCP2 and increases susceptibility to the vascular pathogen Ralstonia solanacearum in Arabidopsis.

Dynamic hydrolase activities precede hypersensitive tissue collapse in tomato seedlings.


DIGE-ABPP by click chemistry: pairwise comparison of serine hydrolase activities from the apoplast of infected plants.

Dynamic hydrolase activities precede hypersensitive tissue collapse in tomato seedlings

Effector specialization in a lineage of the Irish potato famine pathogen

The structural basis of specific protease-inhibitor interactions at the plant-pathogen interface

Selective Conjugation of Proteins by Mining Active Proteomes through Click-Functionalized Magnetic Nanoparticles

Proteolytic Pathways Induced by Herbicides That Inhibit Amino Acid Biosynthesis

Profiling Protein Kinases and Other ATP Binding Proteins in Arabidopsis Using Acyl-ATP Probes

Chemical Proteomics with Sulfonyl Fluoride Probes Reveals Selective Labeling of Functional Tyrosines in Glutathione Transferases

An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana

Pseudomonas syringae pv. syringae Uses Proteasome Inhibitor Syringolin A to Colonize from Wound Infection Sites

A Substrate-Inspired Probe Monitors Translocation, Activation, and Subcellular Targeting of Bacterial Type III Effector Protease AvrPphB

Activity profiling of vacuolar processing enzymes reveals a role for VPE during oomycete infection

RD21 Peptidase

The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains.

Sulfonyl Fluoride Analogues as Activity-Based Probes for Serine Proteases

The maize cystatin CC9 interacts with apoplastic cysteine proteases.

Balancing Selection at the Tomato RCR3 Guardee Gene Family Maintains Variation in Strength of Pathogen Defense

Dual disease resistance mediated by the immune receptor Cf-2 in tomato requires a common virulence target of a fungus and a nematode

Probes for activity-based profiling of plant proteases

Probes for activity‐based profiling of plant proteases

Subclassification and Biochemical Analysis of Plant Papain-Like Cysteine Proteases Displays Subfamily-Specific Characteristics

Post-Translational Regulation and Trafficking of the Granulin-Containing Protease RD21 of Arabidopsis thaliana

A Maize Cystatin Suppresses Host Immunity by Inhibiting Apoplastic Cysteine Proteases

A para-nitrophenol phosphonate probe labels distinct serine hydrolases of Arabidopsis

Labeling and enrichment of Arabidopsis thaliana matrix metalloproteases using an active-site directed, marimastat-based photoreactive probe

Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP

A Role in Immunity for Arabidopsis Cysteine Protease RD21, the Ortholog of the Tomato Immune Protease C14

Activity-based protein profiling of infected plants.

Identification of a Selective, Activity-Based Probe for Glyceraldehyde 3-Phosphate Dehydrogenases

The impact of plant-pathogen studies on medicinal drug discovery

The maize cystatin CC9 interacts with apoplastic cysteine proteases

Phytophthora infestans effector AVRblb2 prevents secretion of a plant immune protease at the haustorial interface

A structural biology perspective on bioactive small molecules and their plant targets

Pseudomonas syringae colonizes distant tissues in Nicotiana benthamiana through xylem vessels

Autophagy differentially controls plant basal immunity to biotrophic and necrotrophic pathogens

A model of the C14-EPIC complex indicates hotspots for a protease-inhibitor arms race in the oomycete-potato interaction.

Mining the active proteome of Arabidopsis thaliana

Proteasome Activity Imaging and Profiling Characterizes Bacterial Effector Syringolin A

An Effector-Targeted Protease Contributes to Defense against Phytophthora infestans and Is under Diversifying Selection in Natural Hosts

Studies on Plant-Pathogen Interactions Using Activity-based Proteomics

Mining the active proteome in plant science and biotechnology

Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defense-induced proteasome activities

Emerging principles in plant chemical genetics

Diversity of Serine Hydrolase Activities of Unchallenged and Botrytis-infected Arabidopsis thaliana

Apoplastic effectors secreted by two unrelated eukaryotic plant pathogens target the tomato defense protease Rcr3

Emerging Concepts in Effector Biology of Plant-Associated Organisms

Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'

beta-Lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana

Enzyme-inhibitor interactions at the plant-pathogen interface

From Guard to Decoy: A new model for perception of plant pathogen effectors

Fungal effector protein AVR2 targets diversifying defense-related Cys proteases of tomato

Papain-like cysteine proteases: key players at molecular battlefields employed by both plants and their invaders

Plant proteases: From phenotypes to molecular mechanisms

Involvement of cathepsin B in the plant disease resistance hypersensitive response.

Small molecule approaches in plants.

A Phytophthora infestans cystatin-like protein targets a novel tomato papain-like apoplastic protease.

Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance.

Structure-function analysis of cf-9, a receptor-like protein with extracytoplasmic leucine-rich repeats.

The plant proteolytic machinery and its role in defence.

Activity profiling of papain-like cysteine proteases in plants.

Rapid migration in gel filtration of the Cf-4 and Cf-9 resistance proteins is an intrinsic property of Cf proteins and not because of their association with high-molecular-weight proteins.

The molecular basis of co-evolution between Cladosporium fulvum and tomato.

Balancing selection favors guarding resistance proteins.

Intragenic recombination generated two distinct Cf genes that mediate AVR9 recognition in the natural population of Lycopersicon pimpinellifolium.

No evidence for binding between resistance gene product Cf-9 of tomato and avirulence gene product AVR9 of Cladosporium fulvum.

The C-terminal dilysine motif for targeting to the endoplasmic reticulum is not required for Cf-9 function.

Identification of distinct specificity determinants in resistance protein Cf-4 allows construction of a Cf-9 mutant that confers recognition of avirulence protein Avr4.

Agroinfiltration is a versatile tool that facilitates comparative analyses of Avr9/Cf-9-induced and Avr4/Cf-4-induced necrosis.

Distinct features of post-transcriptional gene silencing by antisense transgenes in single copy and inverted T-DNA repeat loci.