Professor Lee Sweetlove: List of publications

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Multiple metabolic innovations and losses are associated with major transitions in land plant evolution

Multiple metabolic innovations and losses are associated with major transitions in land plant evolution

Multiple metabolic innovations and losses are associated with major transitions in land plant evolution

Flux balance analysis of metabolism during growth by osmotic cell expansion and its application to tomato fruits

Leaf energy balance requires mitochondrial respiration and export of chloroplast NADPH in the light

Computational analysis of the productivity-potential of CAM plants

Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle

Engineering central metabolism - a grand challenge for plant biologists

Engineering central metabolism - a grand challenge for plant biologists.

Microcompartmentation of cytosolic aldolase by interaction with the actin cytoskeleton in Arabidopsis.

Investigating the Role of the Photorespiratory Pathway in Non-photosynthetic Tissues.

MSL1 is a mechanosensitive ion channel that dissipates mitochondrial membrane potential and maintains redox homeostasis in mitochondria during abiotic stress.

Isolation of Tonoplast Vesicles from Tomato Fruit Pericarp.

A method of accounting for enzyme costs in flux balance analysis reveals alternative pathways and metabolite stores in an illuminated Arabidopsis leaf

Inference and Prediction of Metabolic Network Fluxes.

Heterologous expression of mitochondria-targeted microbial nitrilase enzymes increases cyanide tolerance in Arabidopsis.

A tonoplast Glu/Asp/GABA exchanger that affects tomato fruit amino acid composition.

Heterologous expression of mitochondria-targeted microbial nitrilase enzymes increases cyanide tolerance in Arabidopsis

The 'mitoflash' probe cpYFP does not respond to superoxide.

A Diel Flux Balance Model Captures Interactions between Light and Dark Metabolism during Day-Night Cycles in C3 and Crassulacean Acid Metabolism Leaves.

An Arabidopsis stomatin-like protein affects mitochondrial respiratory supercomplex organization.

Metabolic flux phenotype of tobacco hairy roots engineered for increased geraniol production

Metabolic flux phenotype of tobacco hairy roots engineered for increased geraniol production.

Remarkable reproducibility of enzyme activity profiles in tomato fruits grown under contrasting environments provides a roadmap for studies of fruit metabolism.

Increased β-cyanoalanine nitrilase activity improves cyanide tolerance and assimilation in Arabidopsis.

Mitochondrial Band-7 family proteins: scaffolds for respiratory chain assembly?

Systems analysis of metabolic phenotypes: What have we learnt?

A method for accounting for maintenance costs in flux balance analysis improves the prediction of plant cell metabolic phenotypes under stress conditions

A method for accounting for maintenance costs in flux balance analysis improves the prediction of plant cell metabolic phenotypes under stress conditions.

Modelling metabolic CO2 evolution - A fresh perspective on respiration

Modelling metabolic CO₂ evolution--a fresh perspective on respiration.

Transcriptomic analysis of the role of carboxylic acids in metabolite signaling in Arabidopsis leaves.

Metabolic engineering of tomato fruit organic acid content guided by biochemical analysis of an introgression line.

Systems analysis of metabolic phenotypes: what have we learnt?

The spatial organization of metabolism within the plant cell.

Mitochondrial 'flashes': a radical concept repHined.

Mitochondrial cysteine synthase complex regulates O-acetylserine biosynthesis in plants.

Pulsing of membrane potential in individual mitochondria: a stress-induced mechanism to regulate respiratory bioenergetics in Arabidopsis.

Metabolic recovery of Arabidopsis thaliana roots following cessation of oxidative stress.

The impact of impaired mitochondrial function on retrograde signalling: a meta-analysis of transcriptomic responses.

Metabolic control and regulation of the tricarboxylic acid cycle in photosynthetic and heterotrophic plant tissues

Metabolic control and regulation of the tricarboxylic acid cycle in photosynthetic and heterotrophic plant tissues.

Capturing metabolite channeling in metabolic flux phenotypes.

The circularly permuted yellow fluorescent protein cpYFP that has been used as a superoxide probe is highly responsive to pH but not superoxide in mitochondria: implications for the existence of superoxide 'flashes'.

Alteration of mitochondrial protein complexes in relation to metabolic regulation under short-term oxidative stress in Arabidopsis seedlings

Alteration of mitochondrial protein complexes in relation to metabolic regulation under short-term oxidative stress in Arabidopsis seedlings.

Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis.

The phosphoproteome of Arabidopsis plants lacking the oxidative signal-inducible1 (OXI1) protein kinase.

Flux-balance modeling of plant metabolism.

Metabolic recovery of Arabidopsis thaliana roots following cessation of oxidative stress

A genome-scale metabolic model accurately predicts fluxes in central carbon metabolism under stress conditions.

Not just a circle: flux modes in the plant TCA cycle.

ROS signalling--specificity is required.

Chapter 1 Oxidation of Proteins in Plants-Mechanisms and Consequences

A genome-scale metabolic model of Arabidopsis and some of its properties.

The role of malate in plant homeostasis.

The NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in Arabidopsis.

Monitoring the in vivo redox state of plant mitochondria: effect of respiratory inhibitors, abiotic stress and assessment of recovery from oxidative challenge.

The metabolic response of Arabidopsis roots to oxidative stress is distinct from that of heterotrophic cells in culture and highlights a complex relationship between the levels of transcripts, metabolites, and flux.

Mitochondria biogenesis via Lon1 selective proteolysis: who dares to live for ever?

Role of Lon1 protease in post-germinative growth and maintenance of mitochondrial function in Arabidopsis thaliana.

Metabolic network fluxes in heterotrophic Arabidopsis cells: stability of the flux distribution under different oxygenation conditions.

Confocal imaging of glutathione redox potential in living plant cells.

Decrease in manganese superoxide dismutase leads to reduced root growth and affects tricarboxylic acid cycle flux and mitochondrial redox homeostasis.

Getting to grips with the plant metabolic network.

The use of Proteomics in the Study of Metabolic Control

Glycolytic enzymes associate dynamically with mitochondria in response to respiratory demand and support substrate channeling.

Determination of metabolic fluxes in a non-steady-state system

Determination of metabolic fluxes in a non-steady-state system.

Deficiency of mitochondrial fumarase activity in tomato plants impairs photosynthesis via an effect on stomatal function.

Isolation of intact, functional mitochondria from the model plant Arabidopsis thaliana.

Operation and function of the tricarboxylic acid cycle in the illuminated leaf

Profiling diurnal changes in metabolite and transcript levels in potato leaves

The metabolic response of heterotrophic Arabidopsis cells to oxidative stress.

The mitochondrion: An integration point of cellular metabolism and signalling

Mitochondrial uncoupling protein is required for efficient photosynthesis.

Integrated analysis of metabolite and transcript levels reveals the metabolic shifts that underlie tomato fruit development and highlight regulatory aspects of metabolic network behavior.

Physiological and metabolic adaptations of Potamogeton pectinatus L. tubers support rapid elongation of stem tissue in the absence of oxygen.

Responses to nickel in the proteome of the hyperaccumulator plant Alyssum lesbiacum.

Regulation of metabolic networks: understanding metabolic complexity in the systems biology era.

Profiling of diurnal patterns of metabolite and transcript abundance in potato (Solanum tuberosum) leaves.

Comparison of changes in fruit gene expression in tomato introgression lines provides evidence of genome-wide transcriptional changes and reveals links to mapped QTLs and described traits.

Coordination of nuclear and mitochondrial genome expression during mitochondrial biogenesis in Arabidopsis.

The mitochondrial type II peroxiredoxin F is essential for redox homeostasis and root growth of Arabidopsis thaliana under stress.

Fruit carbohydrate metabolism in an introgression line of tomato with increased fruit soluble solids.

Enhanced photosynthetic performance and growth as a consequence of decreasing mitochondrial malate dehydrogenase activity in transgenic tomato plants.

Application of metabolite profiling to the identification of traits in a population of tomato introgression lines.

Activation and function of mitochondrial uncoupling protein in plants.

A proteomic analysis of plant programmed cell death.

Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport.

Enzymes of glycolysis are functionally associated with the mitochondrion in Arabidopsis cells.

Superoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein.

Predictive metabolic engineering: a goal for systems biology.

Identification of mitochondrial protein complexes in arabidopsis using two-dimensional blue-native polyacrylamide gel electrophoresis

The impact of oxidative stress on Arabidopsis mitochondria.

A custom microarray analysis of gene expression during programmed cell death in Arabidopsis thaliana.

The effect of exogenous sugars on the control of flux by adenosine 5'-diphosphoglucose pyrophosphorylase in potato tuber discs.

Analysis of the Arabidopsis mitochondrial proteome.

Nucleoside diphosphate kinase III is localized to the inter-membrane space in plant mitochondria.

Starch synthesis in transgenic potato tubers with increased 3-phosphoglyceric acid content as a consequence of increased 6-phosphofructokinase activity.

Mitochondrial biogenesis during germination in maize embryos.

Lactate metabolism in potato tubers deficient in lactate dehydrogenase activity

Source metabolism dominates the control of source to sink carbon flux in tuberizing potato plants throughout the diurnal cycle and under a range of environmental conditions

The contribution of adenosine 5'-diphosphoglucose pyrophosphorylase to the control of starch synthesis in potato tubers

The control of source to sink carbon flux during tuber development in potato

Characterization of transgenic potato (Solanum tuberosum) tubers with increased ADPglucose pyrophosphorylase.

Starch metabolism in tubers of transgenic potato (Solanum tuberosum) with increased ADPglucose pyrophosphorylase.

STARCH BIOSYNTHESIS IN POTATO-TUBERS