Professor Renier van der Hoorn

Research Interests

Apoplast manipulation by plant pathogens

We investigate the molecular mechanisms underpinning host manipulation by plant pathogens, with a particular focus on apoplast manipulation of Solanaceous plants by bacterial microbes. One intruiging aspect of this work is the recruitment of an protease in the extracellular recognition of pathogen-derived inhibitors at the plant cell surface by the Cf-2 resistance protein. 

Our research activities also aim at improved molecular pharming of secreted (glyco)proteins through the depletion of extracellular proteases. Unique is our approach to display protein activities by pioneering activity-based protein profiling (ABPP), a powerful functional proteomics technology that offers an exciting platform for collaborations. Please contact us if you are interested to join or collaborate!

Publications
  • BGAL1 depletion boosts the level of β-galactosylation of N- and O-glycans in N. benthamiana.

  • Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method.

  • Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases

  • Proteases of Nicotiana benthamiana: an emerging battle for molecular farming.

  • A homology-guided, genome-based proteome for improved proteomics in the alloploid Nicotiana benthamiana.

  • Activity-based proteomics reveals nine target proteases for the recombinant protein-stabilizing inhibitor SlCYS8 in Nicotiana benthamiana.

  • Triazine Probes Target Ascorbate Peroxidases in Plants.

  • Re-targeting of a plant defense protease by a cyst nematode effector.

  • More
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